Ayush2609/auto_content · Datasets at Hugging Face

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who were diagnosed with hypertension during the period
94.1 � 13.6
Keywords: amlodipine, valsartan, hypertension, hyperlipidemia, LDL
51.8 � 14.1
patients and patients with impaired glucose tolerance
short duration of therapy (12 weeks) because of which we
day)
of atorvastatin (28). However, this fact does not point
DOI: 10.3109/10641963.2012.746355
We probably are not the first group of researchers that may
patients with newly diagnosed essential hypertension. We observed a beneficial effect of amlodipine on the lipid profile
Study. Arterioscler Thromb Vasc Biol 1997; 17(6): 1114–1120.
baseline and after 12 weeks of antihypertensive therapy
agents on serum lipids. Curr Hypertens Rep 2000; 2(4):370–377.
J
Figure 1. Comparison of baseline LDL levels of patients in amlodipine and valsartan groups.
[20] Cheung R, Lewanczuk R, Rodger N, et al. The effect of valsartan
Address correspondence to Mustafa Cakar, MD, Department of Internal Medicine, Gulhane School of Medicine, Tevfik Saglam St., EtlikAnkara 06018, Turkey. E-mail: [email protected]
counts, mean corpuscular volume, and mean platelet
and
223.2 � 38.1
Triglyceride (mg/dL)
mortality reduction, which is acheived by keeping hypertension under control. Recently, several guidelines have
drugs in accordance with the lipid profile.
REFERENCES
angiotensin 2 type 1 receptor, are a relatively new
CONCLUSION
use, it is important and necessary to minimize possible
LDL cholesterol (mg/dL)
.574
spontaneously
observed in levels of TG, LDL, TC, and HDL. The
.832
Baseline
[19] Ogihara T, Yoshinaga K. The clinical efficacy and tolerability of
Table 2. The serum lipid parameters of the amlodipine group at
.906
DISCUSSION
Anthropometric Measurements
amlodipine and atenolol act as immunomodulators of
results
98.1 � 9.6
on the concentration and oxidizability of plasma lipids. Clin Sci
remains controversial (10,11). Several studies report that
7.5 mm Hg, respectively (P < .001).
Abstract
100.0
using a manual mercury sphygmomanometer. Patients
without use of the preparative ultracentrifuge. Clin Chem 1972;
Abbreviations: BMI – body mass index; BSA – body surface area;
29.3 � 7.7
Weidmann P. Effects of angiotensin II-receptor blockade with
atenolol
Sevket Balta,3 Muharrem Akhan,2 Hakan Sarlak,2 Erol Arslan,2 Seref Demirbas,2
levels, but no change in HDL, TGs, very low density lipoprotein(VLDL)cholesterol,andapolipoproteinBlevelswas
hypertensive rats (SHR). Pharmacol Rep 2006; 58(5):711–719.
143.3 � 30.4
lipoprotein (LDL) cholesterol levels are quite strong factors for the development of cardiovascular diseases (3).
height2 (kg/m2).
141.7 � 35.1
in BP lowering when comparing coadministered amlodipine and atorvastatin and amlodipine alone. In a later
Clinical and Experimental Hypertension
TG-low HDL cholesterol and LDL cholesterol to the incidence of
hypertension. Am J Cardiol 2007; 100(2):222–226.
Total cholesterol (mg/dL)
14.3 � 1.1
(ii)
From the past studies, it has been clearly known that
Am
9/12
are unable to assess the type of antihypertensive drug that
IL-6
of
Amlodipine
alcoholism, and smoking and those who were receiving
lipid profiles of newly diagnosed hypertensive patients.
have synergystic effects with statins. In a study by
hypertension. Am J Ther 2003; 10(6):409–414.
total of 43 patients were recruited into the study. Newly
Clin Exp Hypertens Downloaded from informahealthcare.com by Nyu Medical Center on 10/16/14
Triglyceride (mg/dL)
30.4 � 3.8
whereas amlodipine brought an improvement in the lipid
HDL cholesterol (mg/dL)
.942
literature on this subject in newly diagnosed hypertensive
has been shown that dyslipidemia leads to cardiovascular
(n = 22)
decrease in levels of LDL (median LDL, before-after:
in 1660 patients with concomittant hypertension and dyslipidemia: the respond trial. J Clin Pharmacol 2007; 47(12):1555–1569.
in the morning after at least 10 hours of fasting. The
LDL at baseline (mg/dL)
Figure 2. Comparison of LDL levels of patients in valsartan and
.438
200.0
fact, with an additional lowering effect for TC levels.
84.9 � 13.6
effect for cholesterol and TG levels.
TC- and LDL-lowering effects of valsartan (13).
put this heading on the article. The exact mechanism of

who were diagnosed with hypertension during the period

94.1 � 13.6

Keywords: amlodipine, valsartan, hypertension, hyperlipidemia, LDL

51.8 � 14.1

patients and patients with impaired glucose tolerance

short duration of therapy (12 weeks) because of which we

day)

of atorvastatin (28). However, this fact does not point

DOI: 10.3109/10641963.2012.746355

We probably are not the first group of researchers that may

patients with newly diagnosed essential hypertension. We observed a beneficial effect of amlodipine on the lipid profile

Study. Arterioscler Thromb Vasc Biol 1997; 17(6): 1114–1120.

baseline and after 12 weeks of antihypertensive therapy

agents on serum lipids. Curr Hypertens Rep 2000; 2(4):370–377.

J

Figure 1. Comparison of baseline LDL levels of patients in amlodipine and valsartan groups.

[20] Cheung R, Lewanczuk R, Rodger N, et al. The effect of valsartan

Address correspondence to Mustafa Cakar, MD, Department of Internal Medicine, Gulhane School of Medicine, Tevfik Saglam St., EtlikAnkara 06018, Turkey. E-mail: [email protected]

counts, mean corpuscular volume, and mean platelet

and

223.2 � 38.1

Triglyceride (mg/dL)

mortality reduction, which is acheived by keeping hypertension under control. Recently, several guidelines have

drugs in accordance with the lipid profile.

REFERENCES

angiotensin 2 type 1 receptor, are a relatively new

CONCLUSION

use, it is important and necessary to minimize possible

LDL cholesterol (mg/dL)

.574

spontaneously

observed in levels of TG, LDL, TC, and HDL. The

.832

Baseline

[19] Ogihara T, Yoshinaga K. The clinical efficacy and tolerability of

Table 2. The serum lipid parameters of the amlodipine group at

.906

DISCUSSION

Anthropometric Measurements

amlodipine and atenolol act as immunomodulators of

results

98.1 � 9.6

on the concentration and oxidizability of plasma lipids. Clin Sci

remains controversial (10,11). Several studies report that

7.5 mm Hg, respectively (P < .001).

Abstract

100.0

using a manual mercury sphygmomanometer. Patients

without use of the preparative ultracentrifuge. Clin Chem 1972;

Abbreviations: BMI – body mass index; BSA – body surface area;

29.3 � 7.7

Weidmann P. Effects of angiotensin II-receptor blockade with

atenolol

Sevket Balta,3 Muharrem Akhan,2 Hakan Sarlak,2 Erol Arslan,2 Seref Demirbas,2

levels, but no change in HDL, TGs, very low density lipoprotein(VLDL)cholesterol,andapolipoproteinBlevelswas

hypertensive rats (SHR). Pharmacol Rep 2006; 58(5):711–719.

143.3 � 30.4

lipoprotein (LDL) cholesterol levels are quite strong factors for the development of cardiovascular diseases (3).

height2 (kg/m2).

141.7 � 35.1

in BP lowering when comparing coadministered amlodipine and atorvastatin and amlodipine alone. In a later

Clinical and Experimental Hypertension

TG-low HDL cholesterol and LDL cholesterol to the incidence of

hypertension. Am J Cardiol 2007; 100(2):222–226.

Total cholesterol (mg/dL)

14.3 � 1.1

(ii)

From the past studies, it has been clearly known that

Am

9/12

are unable to assess the type of antihypertensive drug that

IL-6

of

Amlodipine

alcoholism, and smoking and those who were receiving

lipid profiles of newly diagnosed hypertensive patients.

have synergystic effects with statins. In a study by

hypertension. Am J Ther 2003; 10(6):409–414.

total of 43 patients were recruited into the study. Newly

Clin Exp Hypertens Downloaded from informahealthcare.com by Nyu Medical Center on 10/16/14

Triglyceride (mg/dL)

30.4 � 3.8

whereas amlodipine brought an improvement in the lipid

HDL cholesterol (mg/dL)

.942

literature on this subject in newly diagnosed hypertensive

has been shown that dyslipidemia leads to cardiovascular

(n = 22)

decrease in levels of LDL (median LDL, before-after:

in 1660 patients with concomittant hypertension and dyslipidemia: the respond trial. J Clin Pharmacol 2007; 47(12):1555–1569.

in the morning after at least 10 hours of fasting. The

LDL at baseline (mg/dL)

Figure 2. Comparison of LDL levels of patients in valsartan and

.438

200.0

fact, with an additional lowering effect for TC levels.

84.9 � 13.6

effect for cholesterol and TG levels.

TC- and LDL-lowering effects of valsartan (13).

put this heading on the article. The exact mechanism of