Re: Free Growth (09-29-17) part 2.pdf
[{"sender": "Robert Trivers", "recipients": ["Alan Rogers", "Jeffrey Epstein [jeevacation@gmail.com]", "Gordon Getty", "Oliver Goodenough", "Tim Kane", "Rob Hanson", "Paul Zak", "Bobby McCormick", "Key Anderson", "Clive Crook", "Matt Ridley", "Gerry Ohrstrom", "Lee Silver", "Monika Gruter Cheney", "Dane Stangler", "Ron Bailey", "Aona Oreber", "Anula Jayasuriya", "Paul Romer", "Vike Cagney", "Evan Sith", "Roger Edelen", "Bill Prezant", "John Mallen", "Jim Halligan", "Marguerite Atkins", "Alex Family Pines", "Ditsa Pines", "David Carst", "president@usfca.edu", "Clair Brown", "Yvette Robbins", "Peter Richerson"], "timestamp": "4/14/2018 5:06:12 PM", "subject": "Re: Free Growth (09-29-17) part 2.pdf", "body": "yes Alan i think you are\n\nyou are referring to duplication of a gene—there are many such genes including those produced by\nretrotransposons (as evidenced by lack of introns)—where a gene has two separate effects and there is an\nadvantage to having a gene with each effect you will often prefer two genes to one, because of less interference\nin fitness effects\n\nPeter was talking about a gene with a single effect—sickling—and the other allele is the normal one—the\nheterozygote destroys malaria within red blood cells at trivial cost and there is no cost at all if malaria is not\npresent—by contrast homozygous sickle individuals suffer lifetime effects\n\nPeter was trying to conjure up a heterozygote that propagated asexually but this requires a chiasma between\nneighbouring genes, a very rare event and hence it usually leads rapidly to mutational decay of one of the two\ncopies, i.e. so-called pseudogenes, of which there are many in our genome\n\nin haste"}, {"sender": "Alan Rogers", "recipients": [], "timestamp": "Thu, Apr 12, 2018 at 11:02 PM", "subject": "Re: Free Growth (09-29-17) part 2.pdf", "body": "haven't read whatever Pete wrote, but if I understand Bob correctly,\nPete must be talking about subfunctionalization:\n\nhttps://en.wikipedia.org/wiki/Subfunctionalization\n\nso, it's not a radical suggestion. It's thought to be the process that\ngave rise to all multi-gene families. Michael Lynch discusses it in his\nbook, The Origin of Genome Architecture.\n\nAm I missing something?\n\nAlan"}, {"sender": "Robert Trivers", "recipients": [], "timestamp": "Thu, Apr 12, 2018 at 3:03 PM", "subject": "Re: Free Growth (09-29-17) part 2.pdf", "body": ""}]