The main product of the following reaction is:
<MultiModal>![CC(C)C[C@@H](O)[C@@](NC(C1=CC=CC=C1)=O)(C(OC)=O)CC=C reacts with $SOCl_2$ in THF solvent at room temperature](/media/uploads/6415cd51-034f-4a74-aaaa-0d796b59c52c.png)</MultiModal>
Several options are given showing the structures of reaction substrates and the absolute configurations of carbon atoms. Select the correct one.
下列反应的主产物为：
<MultiModal>![CC(C)C[C@@H](O)[C@@](NC(C1=CC=CC=C1)=O)(C(OC)=O)CC=C在THF溶剂中与$SOCl_2$在室温下发生反应](/media/uploads/6415cd51-034f-4a74-aaaa-0d796b59c52c.png)</MultiModal>
选项给出了几个反应底物的结构和碳原子绝对构型，选择正确的一项。
<MultiModal>![C=CC[C@]1(C(OC)=O)[C@@H](CC(C)C)OC(C2=CC=CC=C2)=N1](/media/uploads/fc73803b-eafa-43c2-8957-e0a622f40bee.png)</MultiModal>  

The carbon connected to O is in the R configuration, and the carbon connected to N is in the R configuration.
<MultiModal>![C=CC[C@]1(C(OC)=O)[C@H](CC(C)C)OC(C2=CC=CC=C2)=N1](/media/uploads/d373c30c-3f55-43db-bd12-c280ccc5547a.png)</MultiModal>  

The carbon connected to O is in the S configuration, and the carbon connected to N is in the R configuration.
<MultiModal>![CC(C)/C=C/[C@@](NC(C1=CC=CC=C1)=O)(C(OC)=O)CC=C](/media/uploads/d19e89b5-279b-43b4-afb4-fae03871fd80.png)</MultiModal>  

The carbon is of R configuration
<MultiModal>![C=CC[C@]1(C(OC)=O)[C@@]([H])(N1C(C2=CC=CC=C2)=O)CC(C)C](/media/uploads/8493ba94-683c-4b2c-85ce-caa4cb734ffb.png)</MultiModal>  

The carbon bonded to the hydrogen atom has an S configuration, while the other carbon has an R configuration.
<MultiModal>![CC(C)C[C@]1([H])CC=C[C@]1(NC(C2=CC=CC=C2)=O)C(OC)=O](/media/uploads/54324117-1217-43e1-a743-fb3b45867fc6.png)</MultiModal>  

The carbon connected to the nitrogen atom is in the R configuration, and the carbon connected to the hydrogen atom is in the R configuration
<MultiModal>![CC(C)C[C@]1([H])C=CC[C@]1(NC(C2=CC=CC=C2)=O)C(OC)=O](/media/uploads/b7a1a74a-a167-4ef7-9698-47ea6cd99aae.png)</MultiModal>

The carbon bonded to the nitrogen atom has an R configuration, and the carbon bonded to the hydrogen atom has an R configuration.
<MultiModal>![C=CC[C@]1(C(OC)=O)[C@@H](CC(C)C)OC(C2=CC=CC=C2)=N1](/media/uploads/fc73803b-eafa-43c2-8957-e0a622f40bee.png)</MultiModal>

与氧原子相连的碳是R构型,与氮原子相连的碳是R构型
<MultiModal>![C=CC[C@]1(C(OC)=O)[C@H](CC(C)C)OC(C2=CC=CC=C2)=N1](/media/uploads/d373c30c-3f55-43db-bd12-c280ccc5547a.png)</MultiModal>

与氧原子相连的碳是S构型,与氮原子相连的碳是R构型
<MultiModal>![CC(C)/C=C/[C@@](NC(C1=CC=CC=C1)=O)(C(OC)=O)CC=C](/media/uploads/d19e89b5-279b-43b4-afb4-fae03871fd80.png)</MultiModal>

碳是R构型
<MultiModal>![C=CC[C@]1(C(OC)=O)[C@@]([H])(N1C(C2=CC=CC=C2)=O)CC(C)C](/media/uploads/8493ba94-683c-4b2c-85ce-caa4cb734ffb.png)</MultiModal>

与氢原子相连的碳是S构型,另一个碳是R构型

<MultiModal>![CC(C)C[C@]1([H])CC=C[C@]1(NC(C2=CC=CC=C2)=O)C(OC)=O](/media/uploads/54324117-1217-43e1-a743-fb3b45867fc6.png)</MultiModal>

与氮原子相连的碳是R构型,与氢原子相连的碳是R构型
<MultiModal>![CC(C)C[C@]1([H])C=CC[C@]1(NC(C2=CC=CC=C2)=O)C(OC)=O](/media/uploads/b7a1a74a-a167-4ef7-9698-47ea6cd99aae.png)</MultiModal>

与氮原子相连的碳是R构型,与氢原子相连的碳是R构型
$SOCl_2$ as a dehydrating agent first reacts with the hydroxyl group to form a chlorosulfite ester intermediate  

<MultiModal>![CC(C)C[C@@H](OS(Cl)=O)[C@@](NC(C1=CC=CC=C1)=O)(C(OC)=O)CC=C](/media/uploads/64f012dd-4ba1-49cd-96f3-e04428a9272e.png)</MultiModal>  

<Checkpoint>[$SOCl_2$ as a dehydrating agent first reacts with the hydroxyl group to form a chlorosulfite ester intermediate](1)</Checkpoint>  

The formation of a five-membered ring is more favorable than a three-membered ring. The oxygen atom in the amide group can act as a nucleophile to attack the adjacent carbon atom, undergoing a nucleophilic substitution reaction and eliminating a molecule of $SO_2$ to form a five-membered ring structure.  

<Checkpoint>[The oxygen atom in the amide group can act as a nucleophile to attack the adjacent carbon atom, undergoing a nucleophilic substitution reaction and eliminating a molecule of $SO_2$ to form a five-membered ring structure](1)</Checkpoint>  

The carbon atom bonded to oxygen undergoes inversion of configuration during the reaction.  

<Checkpoint>[The carbon atom bonded to oxygen undergoes inversion of configuration during the reaction](1)</Checkpoint>
$SOCl_2$作为脱水剂首先与羟基反应，形成氯代亚硫酸酯中间体

<MultiModal>![CC(C)C[C@@H](OS(Cl)=O)[C@@](NC(C1=CC=CC=C1)=O)(C(OC)=O)CC=C](/media/uploads/64f012dd-4ba1-49cd-96f3-e04428a9272e.png)</MultiModal>

<Checkpoint>[$SOCl_2$作为脱水剂首先与羟基反应，形成氯代亚硫酸酯中间体](1)</Checkpoint>



形成五元环比三元环更有利，酰胺基团中的氧原子可以作为亲核试剂攻击邻近的碳原子发生亲核取代反应，脱去一分子$SO_2$形成五元环结构

<Checkpoint>[酰胺基团中的氧原子可以作为亲核试剂攻击邻近的碳原子发生亲核取代反应，脱去一分子$SO_2$形成五元环结构](1)</Checkpoint>

反应过程中与氧相连的碳原子会发生构型翻转

<Checkpoint>[反应过程中与氧相连的碳原子会发生构型翻转](1)</Checkpoint>