Microwave catalysis is based on the unique thermal effects generated by the principle of dielectric heating, which can lead to a significant increase in reaction rates.  

<MultiModal>![NC1=CC(C2=CC=CC=C2)=NN1.O=C(C1=CC=CC=C1)[H].O=C1CC(C)(C)CC(C1)=O>$EtOH$, $Et_3N$ MW, $150\degree\mathrm{C}$, 15 min>B](/media/uploads/8f775c1d-f5c1-4c7e-922e-94e4caeeae13.png)</MultiModal>  

Please attempt to predict the product B of the above reaction and indicate how many stereocenters the product possesses.
微波催化是基于介电加热原理产生的独特热效应，可以导致反应速率的显著提升。

<MultiModal>![NC1=CC(C2=CC=CC=C2)=NN1.O=C(C1=CC=CC=C1)[H].O=C1CC(C)(C)CC(C1)=O>$EtOH$, $Et_3N$ MW, $150\degree\mathrm{C}$, 15 min>B](/media/uploads/8f775c1d-f5c1-4c7e-922e-94e4caeeae13.png)</MultiModal>

请尝试预测上述反应的产物B，并指出该产物具有几种手性中心
<MultiModal>![O=C1C2=C(NC3=CC(C4=CC=CC=C4)=NN3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/956cdbf5-9128-47d4-a366-0458adefd5b2.png)</MultiModal>

There are 2 chiral centers
<MultiModal>![O=C1C2=C(NC3=CC(C4=CC=CC=C4)=NN3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/956cdbf5-9128-47d4-a366-0458adefd5b2.png)</MultiModal>

There is 1 chiral center
<MultiModal>![O=C1C2=C(NC3=CC(C4=CC=CC=C4)=NN3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/956cdbf5-9128-47d4-a366-0458adefd5b2.png)</MultiModal>

There are 0 chiral centers
<MultiModal>![O=C1C2=C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/143873d3-1f8b-47e2-9ea0-70b2cdab6ee7.png)</MultiModal>  

There are 2 chiral centers
<MultiModal>![O=C1C2=C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/143873d3-1f8b-47e2-9ea0-70b2cdab6ee7.png)</MultiModal>  

There is 1 chiral center
<MultiModal>![O=C1C2=C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/143873d3-1f8b-47e2-9ea0-70b2cdab6ee7.png)</MultiModal>

There are 0 chiral centers
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/672dbbdc-023b-4c96-b6a2-34d7d5a83548.png)</MultiModal>

There are 2 chiral centers
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/672dbbdc-023b-4c96-b6a2-34d7d5a83548.png)</MultiModal>

There is 1 chiral center
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/672dbbdc-023b-4c96-b6a2-34d7d5a83548.png)</MultiModal>  

There are 0 chiral centers
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/40a62df1-fecc-4628-9a4e-c0760b853bbe.png)</MultiModal>

There are 2 chiral centers
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/40a62df1-fecc-4628-9a4e-c0760b853bbe.png)</MultiModal>

There is 1 chiral center
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/40a62df1-fecc-4628-9a4e-c0760b853bbe.png)</MultiModal>

There are 0 chiral centers
<MultiModal>![O=C1C2=C(NC3=CC(C4=CC=CC=C4)=NN3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/956cdbf5-9128-47d4-a366-0458adefd5b2.png)</MultiModal>

有2个手性中心
<MultiModal>![O=C1C2=C(NC3=CC(C4=CC=CC=C4)=NN3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/956cdbf5-9128-47d4-a366-0458adefd5b2.png)</MultiModal>

有1个手性中心
<MultiModal>![O=C1C2=C(NC3=CC(C4=CC=CC=C4)=NN3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/956cdbf5-9128-47d4-a366-0458adefd5b2.png)</MultiModal>

有0个手性中心
<MultiModal>![O=C1C2=C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/143873d3-1f8b-47e2-9ea0-70b2cdab6ee7.png)</MultiModal>

有2个手性中心

<MultiModal>![O=C1C2=C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/143873d3-1f8b-47e2-9ea0-70b2cdab6ee7.png)</MultiModal>

有1个手性中心
<MultiModal>![O=C1C2=C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/143873d3-1f8b-47e2-9ea0-70b2cdab6ee7.png)</MultiModal>

有0个手性中心
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/672dbbdc-023b-4c96-b6a2-34d7d5a83548.png)</MultiModal>

有2个手性中心
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/672dbbdc-023b-4c96-b6a2-34d7d5a83548.png)</MultiModal>

有1个手性中心
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/672dbbdc-023b-4c96-b6a2-34d7d5a83548.png)</MultiModal>

有0个手性中心
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/40a62df1-fecc-4628-9a4e-c0760b853bbe.png)</MultiModal>

有2个手性中心
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/40a62df1-fecc-4628-9a4e-c0760b853bbe.png)</MultiModal>

有1个手性中心
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/40a62df1-fecc-4628-9a4e-c0760b853bbe.png)</MultiModal>

有0个手性中心
Under the conditions of adding triethylamine and a reaction temperature of $150\degree\mathrm{C}$, the reaction yields the thermodynamic product.

<Checkpoint>[The reaction yields the thermodynamic product](1)</Checkpoint>

The formation of a carbon-carbon single bond during ring closure is thermodynamically more stable than the formation of a carbon-nitrogen single bond.

<Checkpoint>[The formation of a carbon-carbon single bond during ring closure is thermodynamically more stable than the formation of a carbon-nitrogen single bond](1)</Checkpoint>

First, the condensation reaction intermediate is obtained <MultiModal>![O=C1C2C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)(O)CC(C)(C)C1](/media/uploads/9a7445f2-edb9-45b3-a03f-7741efd5ef4f.png)</MultiModal>

<Checkpoint>[First, the condensation reaction intermediate is obtained <MultiModal>![O=C1C2C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)(O)CC(C)(C)C1](/media/uploads/9a7445f2-edb9-45b3-a03f-7741efd5ef4f.png)</MultiModal>](1)</Checkpoint>

Finally, a molecule of water is lost to yield the final product E.

Clearly, this product has only one stereocenter.
在加入三乙胺以及反应温度为$150\degree\mathrm{C}$的条件下，反应会得到热力学产物

<Checkpoint>[反应会得到热力学产物](1)</Checkpoint>

成环时生成碳碳单键比生成碳氮单键更具有热力学稳定性

<Checkpoint>[成环时生成碳碳单键比生成碳氮单键更具有热力学稳定性](1)</Checkpoint>

首先得到缩合反应中间体 <MultiModal>![O=C1C2C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)(O)CC(C)(C)C1](/media/uploads/9a7445f2-edb9-45b3-a03f-7741efd5ef4f.png)</MultiModal>

<Checkpoint>[首先得到缩合反应中间体 <MultiModal>![O=C1C2C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)(O)CC(C)(C)C1](/media/uploads/9a7445f2-edb9-45b3-a03f-7741efd5ef4f.png)</MultiModal>](1)</Checkpoint>

最后失去一分子水得到最终产物E

显然该产物只有1个手性中心