<MultiModal>![NC1=CC(C2=CC=CC=C2)=NN1.O=C(C1=CC=CC=C1)[H].O=C1CC(C)(C)CC(C1)=O>$EtOH$, $tBuOK$ MW, $150\degree\mathrm{C}$, 15 min>C](/media/uploads/aaf58999-c6b4-47ca-9a8f-4cffc0c39817.png)</MultiModal>

Without considering enantiomers, please predict the product C of this reaction (molecular formula: $\mathrm{C_{24}H_{25}N_3O_2}$), and indicate how many rings are in this structure.
<MultiModal>![NC1=CC(C2=CC=CC=C2)=NN1.O=C(C1=CC=CC=C1)[H].O=C1CC(C)(C)CC(C1)=O>$EtOH$, $tBuOK$ MW, $150\degree\mathrm{C}$, 15 min>C](/media/uploads/aaf58999-c6b4-47ca-9a8f-4cffc0c39817.png)</MultiModal>

不考虑对映异构体的情况下请预测该反应的产物C（分子式：$\mathrm{C_{24}H_{25}N_3O_2}$），并指出该结构中有几个环
<MultiModal>![O=C1C2=C(NC3=CC(C4=CC=CC=C4)=NN3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/956cdbf5-9128-47d4-a366-0458adefd5b2.png)</MultiModal>

This structure contains 6 rings
<MultiModal>![O=C1C2=C(NC3=CC(C4=CC=CC=C4)=NN3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/956cdbf5-9128-47d4-a366-0458adefd5b2.png)</MultiModal>  

This structure contains 5 rings
<MultiModal>![O=C1C2=C(NC3=CC(C4=CC=CC=C4)=NN3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/956cdbf5-9128-47d4-a366-0458adefd5b2.png)</MultiModal>  

There are 8 rings in this structure
<MultiModal>![O=C1C2=C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/143873d3-1f8b-47e2-9ea0-70b2cdab6ee7.png)</MultiModal>

There are 6 rings in this structure
<MultiModal>![O=C1C2=C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/143873d3-1f8b-47e2-9ea0-70b2cdab6ee7.png)</MultiModal>

This structure contains 5 rings
<MultiModal>![O=C1C2=C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/143873d3-1f8b-47e2-9ea0-70b2cdab6ee7.png)</MultiModal>  

This structure contains 8 rings
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/672dbbdc-023b-4c96-b6a2-34d7d5a83548.png)</MultiModal>

There are 6 rings in this structure
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/672dbbdc-023b-4c96-b6a2-34d7d5a83548.png)</MultiModal>  

There are 5 rings in this structure
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/672dbbdc-023b-4c96-b6a2-34d7d5a83548.png)</MultiModal>  

There are 8 rings in this structure
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/40a62df1-fecc-4628-9a4e-c0760b853bbe.png)</MultiModal>

This structure contains 6 rings
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/40a62df1-fecc-4628-9a4e-c0760b853bbe.png)</MultiModal>

There are 5 rings in this structure
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/40a62df1-fecc-4628-9a4e-c0760b853bbe.png)</MultiModal>  

This structure contains 8 rings
<MultiModal>![O=C1C2=C(NC3=CC(C4=CC=CC=C4)=NN3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/956cdbf5-9128-47d4-a366-0458adefd5b2.png)</MultiModal>

该结构中有6个环
<MultiModal>![O=C1C2=C(NC3=CC(C4=CC=CC=C4)=NN3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/956cdbf5-9128-47d4-a366-0458adefd5b2.png)</MultiModal>

该结构中有5个环
<MultiModal>![O=C1C2=C(NC3=CC(C4=CC=CC=C4)=NN3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/956cdbf5-9128-47d4-a366-0458adefd5b2.png)</MultiModal>

该结构中有8个环
<MultiModal>![O=C1C2=C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/143873d3-1f8b-47e2-9ea0-70b2cdab6ee7.png)</MultiModal>

该结构中有6个环
<MultiModal>![O=C1C2=C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/143873d3-1f8b-47e2-9ea0-70b2cdab6ee7.png)</MultiModal>

该结构中有5个环
<MultiModal>![O=C1C2=C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)CC(C)(C)C1](/media/uploads/143873d3-1f8b-47e2-9ea0-70b2cdab6ee7.png)</MultiModal>

该结构中有8个环
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/672dbbdc-023b-4c96-b6a2-34d7d5a83548.png)</MultiModal>

该结构中有6个环
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/672dbbdc-023b-4c96-b6a2-34d7d5a83548.png)</MultiModal>

该结构中有5个环
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/672dbbdc-023b-4c96-b6a2-34d7d5a83548.png)</MultiModal>

该结构中有8个环
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/40a62df1-fecc-4628-9a4e-c0760b853bbe.png)</MultiModal>

该结构中有6个环
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/40a62df1-fecc-4628-9a4e-c0760b853bbe.png)</MultiModal>

该结构中有5个环
<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/40a62df1-fecc-4628-9a4e-c0760b853bbe.png)</MultiModal>

该结构中有8个环
The reaction yields thermodynamically stable products under the condition of $150\degree\mathrm{C}$  

<Checkpoint>[The reaction yields thermodynamically stable products under the condition of $150\degree\mathrm{C}$](1)</Checkpoint>  

The carbon-carbon single bond is more stable than the carbon-nitrogen single bond during ring formation.  

<Checkpoint>[The carbon-carbon single bond is more stable than the carbon-nitrogen single bond during ring formation](1)</Checkpoint>  

Thus, the reaction initially forms an intermediate.  

<MultiModal>![O=C1C2C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)(O)CC(C)(C)C1](/media/uploads/f7f0445f-c968-492d-919d-b7726fbca4b6.png)</MultiModal>  

<Checkpoint>[Thus, the reaction initially forms an intermediate  <MultiModal>![O=C1C2C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)(O)CC(C)(C)C1](/media/uploads/f7f0445f-c968-492d-919d-b7726fbca4b6.png)</MultiModal>](1)</Checkpoint>  

Subsequently, under the action of a strong base, $tBuO^-$ or $EtO^-$ nucleophilically attacks the carbonyl group, leading to ring opening.  

<MultiModal>![CC(CC1(O)[CH-]C(C2=CC=CC=C2)C3=C(NN=C3C4=CC=CC=C4)N1)(C)CC(O[R])=O](/media/uploads/39b6d8ae-c1de-4f5e-ac1f-6e75758a4886.png)</MultiModal>  

<Checkpoint>[Subsequently, under the action of a strong base, $tBuO^-$ or $EtO^-$ nucleophilically attacks the carbonyl group, leading to ring opening  <MultiModal>![CC(CC1(O)[CH-]C(C2=CC=CC=C2)C3=C(NN=C3C4=CC=CC=C4)N1)(C)CC(O[R])=O](/media/uploads/39b6d8ae-c1de-4f5e-ac1f-6e75758a4886.png)</MultiModal>](1)</Checkpoint>  

After proton exchange, further ring closure forms a stable lactam product.  

<Checkpoint>[After proton exchange, further ring closure forms a stable lactam product](1)</Checkpoint>  

<Checkpoint>[The phenyl group in the equatorial position is the thermodynamically stable product](1)</Checkpoint>  

<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/a1351735-6983-4571-9d30-1916351b3d8b.png)</MultiModal>
该反应在$150\degree\mathrm{C}$条件下，生成热力学稳定的产物

<Checkpoint>[该反应在$150\degree\mathrm{C}$条件下，生成热力学稳定的产物](1)</Checkpoint>

成环时碳碳单键比碳氮单键更加稳定

<Checkpoint>[成环时碳碳单键比碳氮单键更加稳定](1)</Checkpoint>

因此首先反应形成中间体

<MultiModal>![O=C1C2C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)(O)CC(C)(C)C1](/media/uploads/f7f0445f-c968-492d-919d-b7726fbca4b6.png)</MultiModal>

<Checkpoint>[因此首先反应形成中间体  <MultiModal>![O=C1C2C(NC(NN=C3C4=CC=CC=C4)=C3C2C5=CC=CC=C5)(O)CC(C)(C)C1](/media/uploads/f7f0445f-c968-492d-919d-b7726fbca4b6.png)</MultiModal>](1)</Checkpoint>

随后在强碱的作用下，$tBuO^-$或者$EtO^-$会对羰基进行亲核进攻后开环  

<MultiModal>![CC(CC1(O)[CH-]C(C2=CC=CC=C2)C3=C(NN=C3C4=CC=CC=C4)N1)(C)CC(O[R])=O](/media/uploads/39b6d8ae-c1de-4f5e-ac1f-6e75758a4886.png)</MultiModal>

<Checkpoint>[随后在强碱的作用下，$tBuO^-$或者$EtO^-$会对羰基进行亲核进攻后开环  <MultiModal>![CC(CC1(O)[CH-]C(C2=CC=CC=C2)C3=C(NN=C3C4=CC=CC=C4)N1)(C)CC(O[R])=O](/media/uploads/39b6d8ae-c1de-4f5e-ac1f-6e75758a4886.png)</MultiModal>](1)</Checkpoint>

质子交换之后进一步成环形成稳定的内酰胺产物

<Checkpoint>[质子交换之后进一步成环形成稳定的内酰胺产物](1)</Checkpoint>

<Checkpoint>[苯基位于平伏键时为热力学稳定的产物](1)</Checkpoint>

<MultiModal>![O=C1N2C3=C(C(C4=CC=CC=C4)=NN3)[C@]([H])(C5=CC=CC=C5)C[C@]2(O)CC(C)(C)C1](/media/uploads/a1351735-6983-4571-9d30-1916351b3d8b.png)</MultiModal>