Targeting Solute Carriers using Recombinant Antibodies.
Carlsberg Foundation
Aalborg University
Membrane proteins play an essential role in translating extracellular cues into intracellular responses, a feature making them attractive drug targets. Thus, it is not surprising that while membrane proteins make up around 30% of human genes, they account for over 60% of all drug targets. The solute carrier (SLC) superfamily constitutes the largest group of membrane proteins, transporting a vast array of important molecules across membranes. This superfamily of membrane proteins include more than 450 proteins. Despite being attractive and druggable targets, the SLCs, for a major part, remains understudied. Availability of reliable and validated tools to study the distribution, function and behavior remain a major bottleneck. In the current project we select recombinant antibodies for SLCs. What? Why? How?
Research Infrastructure / Research Infrastructure / Award