Impact of birthweight on early cardiometabolic disease manifestations in the aging Inter99 cohort - a 20-year deep phenotyping follow-up study.
Novo Nordisk Foundation
Steno Diabetes Center Copenhagen
Since 2021 we have performed a 20-years follow-up study of the now 50 to 80 years old participants of the Inter99 cohort. We aim to understand whether genetics (DNA), adult lifestyle (diet, physical activity, and obesity), and/or especially factors operating before birth, reflected as a low birthweight (LBW), may be involved in development of Type 2 diabetes (T2D) and its complications. Our examinations of the around 2300 people with and without T2D includes weight, height, fat mass, blood pressure, muscle strength, stiffness of vessels, arteriosclerosis in the heart, liver fat, nerve function, eye background changes as well as kidney function. The results will provide important insights into whether LBW in a non-genetic manner influence early signs of T2D related complications in both T2D patients, and in elderly people with normal glucose levels for 20 years. All five Steno Diabetes Centers (SDC), starting with SDC Aarhus, will be invited to join the existing Inter99 collaboration.
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