Assessment of ataxia severity under real-life conditions with SARAhome: A multicenter study in spinocerebellar ataxia type 3 (SCA3)
Ataxia UK
Helmholtz Association of German Research Centres
The aim of the project is to study ataxia severity under real-life conditions in a large cohort of spinocerebellar ataxia type 3 (SCA3) patients. To this end, the researchers will employ SARAhome, a newly developed video-based digital assessment tool. The study will be performed as a substudy of the ESMI cohort. This study will allow for the first time to assess fluctuation of ataxia in SCA3 over a period of 14 days. Specifically, they wish to quantify the extent of fluctuations and identify causative factors. In addition, the study will give more information on the relation of SARAhome ratings to the conventional SARA obtained in the hospital, feasibility of SARAhome in a multicentre setting, and the minimum number of days of home assessment required to obtain a representative measure of ataxia severity.
4.1 Discovery and preclinical testing of markers and technologies