Brain-gut-pancreas immune axis regulates FoxA1+Tregulatory cells to prevent multi-organ inflammation
Novo Nordisk Foundation
University of Copenhagen
Inflammatory diseases like inflammatory bowel disorders, diabetes, and brain inflammatory disease, multiple sclerosis are among growing diseases worldwide. These illnesses afflict more than 23.5 million people in America alone, and the prevalence is rising, expected to double over the next 25 years. These diseases are mainly caused by disturbed immune cells. Immune cells normally are responsible for patrolling body for search of invading bacteria and viruses, to fight and clean them, and finally withdraw from the fight. However, sometimes immune cells get confused and keep attacking our own tissues causing chronic inflammatory illnesses. Therefore, it is important to understand how these diseases are developing and how to change the fate of inflammatory immune cells to become anti-inflammatory and withdraw from harm-causing. We have identified one such group of cells called FoxA1+Tregulatory cells. We wish to study if they are relevant for controlling inflammatory diseases.
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