FEDER - JOHNSON&JOHNSON - Nerveskin
Kohesio
JOHNSON ET JOHNSON SANTE BEAUTE FRANCE
The existence of sensitive skin is both internal (stress, lack of sleep) and external (pollution, UV, etc.) in origin. However, few cosmetic solutions are offered to relieve sensitive skin. The main discomfort of sensitive skin is pruritus: an unpleasant sensation leading to the need to scratch and to fairly debilitating inflammatory skin pathologies associated with a dysregulation of neuro-cutaneous interactions. 1/3 of the world population (2.5 billion people) has been subject to notable itching, localized to one part of the body or even generalized. Also nearly 10-50% (0.75-3 billion people) consider they have sensitive skin regardless of whether it is itchy or not. The dermo-cosmetics market is still young and growing. In almost 15 years, it has more than doubled. Western Europe represents 60% of the global market compared to 22% of the total beauty market. It is therefore necessary to develop cosmetic products adapted to relieve/treat these associated skin disturbances. “Everyone” consumers buy through pharmacies and supermarkets. Pharmacies are at the heart of the dermocosmetics market. In Western Europe, they represent, with drugstores, 25% of skin care sales. In the United States as in Brazil and China, pharmacy does not always benefit from the same attractiveness as in Western Europe. Consumers prefer to turn more to drugstores, shopping malls and department stores. To study pruritus or sensitive skin, and evaluate active ingredients, there are a multitude of cellular models. It is rather easy to find primary human skin cells, however for neurons there is no economical or practical solution. The techniques used for the identification of plant raw materials with soothing properties are limited to a phenotypic approach (without a mechanism of action targeted at a particular receptor).¿ The mechanisms of action of existing products are often associated with a reduction in skin inflammation or a restoration of the barrier function. ¿Few ingredients have been developed with an approach targeting sensory neurons for a more complete and lasting action. ¿The formulation of new products is today time-consuming, expensive and not universal. These products have a limited action and their mechanism of action is very little described. The NERVESKIN project aims to develop cosmetic products for sensitive skin, using natural molecules, tested and validated on re-innervated skin explants.
Smarter Europe / Research and innovation / Technology transfer and university-enterprise cooperation primarily benefiting SMEs