Single-cell Tracking Analytics for Reliable Bioprocesses (STARBio), Associate Professor, Stefan Junne
Novo Nordisk Foundation
Aalborg University
Understanding the impact of the growth environment on individual cells and their interaction within populations across different bioreactor types and scales is important for i) an advanced process monitoring and control to achieve a high process robustness, especially for co- and mixed cultures; ii) the replacement of sophisticated off line measurements for the quantification of intracellular components like lipids, biopolymers, inclusion bodies; iii) faster process development with respect to scale down and scale up, while considering macromorphological and population changes; and iv) an improved process simulation under consideration of the population, e.g. through population balance analysis. Single cell assessment technologies will be further developed and used as process analytical tools in bioprocesses, involving interdisciplinary use of imaging techniques in close cooperation with research associates specializing in measurement and control technology and machine learning.
Research / Investigators / Award