Advanced in Vitro Test Systems with Integrated Multi-"OMICS" to define Pathway Activation and Treatment Response Scores for Patient Stratification Towards Personalised Medicine in Systemic Sclerosis
Scleroderma & Raynaud's UK
Düsseldorf University Hospital
Develop a novel toolset for the molecular stratification of ssc patients to ensure they are put on the most appropriate therapies, therefore justifying the potential side effects of these therapies. Precision cut skin slices will be exposed to treatment candidates, monitored, and using biostatics an activation score for each treatment will be generated. Treatment specific signatures will also be generated to predict the likelihood of individual patients to respond to specific therapies.
4.2 Evaluation of markers and technologies