TOWARDS PRECISION MEDICINE IN SURGERY – AN INTEGRATIVE APPROACH COMBINING DEEP LEARNING, GENETICS AND EPIGENETICS.
Novo Nordisk Foundation
Copenhagen University Hospital
Worldwide, an estimated 234 million surgical procedures are performed each year. While many patients proceed to an uneventful recovery, 15% of procedures are complicated by adverse events (AE’s), including strokes, heart attacks, blood clots and wound infections. These directly result in a 4% risk of death following surgery worldwide. Aside from the impact on the patient, AE’s increase health care costs up to 172%.Accurate risk prediction is thus pivotal for both the patient and society as a whole. With this project, we seek to assess the role of genetics and epigenetics in surgical AE’s. Furthermore, we will evaluate whether artificial intelligence can assist in both surgical risk prediction as well as the identification of genetic and epigenetic factors of relevance to surgical outcomes. To do this, we have established an international collaboration with Harvard and Michigan Universities, with the hope of collectively identifying novel factors that can reduce surgical AE’s
Research Projects (Max 10 MDKK) / Investigators / Award