Laparotomy vs. Drainage for Infants With Necrotizing Enterocolitis
National Center for Research Resources (NCRR)
Stanford University

      This trial will compare the effectiveness of two surgical procedures -laparotomy versus
      drainage - commonly used to treat necrotizing enterocolitis (NEC) or isolated intestinal
      perforations (IP) in extremely low birth weight infants (≤1,000 g). Infants diagnosed with
      NEC or IP requiring surgical intervention, will be recruited. Subjects will be randomized to
      receive either a laparotomy or peritoneal drainage. Primary outcome is impairment-free
      survival at 18-22 months corrected age.
    
Procedure