In Adipose Tissue: Identifying Genetic Mechanisms that Uncouple Obesity from Insulin Resistance
Novo Nordisk Foundation
University of Copenhagen
Obesity often leads to insulin resistance and an increased risk of type 2 diabetes. However, not all individuals with obesity are similarly affected. Given the same weight gain, individuals may be either protected from or predisposed to insulin resistance. The aim of the present project is to understand the reasons for these individual differences through genetic studies. Previously, we have found that certain DNA variants lead to a person having higher body fat but lower insulin resistance and diabetes-risk than others. We have also found that these DNA variants relate to differences in the properties of the fat tissue that the person carries. In the present project, we will use a combination of genetic studies and laboratory experiments to explain how the DNA variants change the properties of fat tissue and protect from insulin resistance and diabetes-risk. This new understanding may point towards new ways of treating obesity-related insulin resistance and diabetes.
Research Projects (Max 10 MDKK) / Investigators / Award