The Economies of Ox: Scaling up Oxidative Processes to Streamline Synthesis
The Finnish Research Impact Foundation
University of Jyväskylä
The main goal of the project is to develop safe, scalable methods for oxidations and oxidative couplings for use in the production of active pharmaceutical ingredients (APIs) by chemical synthesis. Oxidations and oxidative reactions are some of the most challenging reactions to scale up in pharmaceutical production. Nevertheless, increasing the oxidation state of the molecule by these reactions often provides very attractive shortcuts to synthetic production routes, cutting off the number of steps and providing alternative, less wasteful and less costly methods for synthesis. The goal of this project is to develop safe oxidation and oxidative coupling methods based on catalytic transfer oxidations and other benign terminal oxidants, bearing the scalability and safety always in mind.
Tandem Industry Academia (2020)