Diagnostics of autoimmune liver diseases by mass-spectrometry based proteomics
Novo Nordisk Foundation
Copenhagen University Hospital - Bispebjerg and Frederiksberg
Autoimmune liver diseases are relatively rare, chronic liver diseases which may affect people of all ages. Left untreated, the diseases progress to irreversible cirrhosis, liver failure, or cancer making it important to diagnose the diseases as early as possible. Unfortunately, current diagnostic liver blood tests are non-specific markers of liver damage, and a liver biopsy (tissue sample) is often required but may be inconclusive. The primary aim of this project is to identify new and better diagnostic markers of these diseases. To accomplish this, we use modern technology omics-based analyses on liver tissue and blood from 125 patients with autoimmune liver diseases and 25 healthy control participants recruited from the Gastro Unit, Copenhagen University Hospital Hvidovre. The results will provide insight into disease mechanisms including the discovery of new biomarker candidates and aid the identification of new treatments.
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