Standard Drug Therapy vs. Implanted Defibrillator for Primary Prevention of Sudden Cardiac Death
Ontario Ministry of Health and Long Term Care
St. Michael's Hospital, Toronto

      Recent ACC/AHA/ESC guidelines recommend prophylactic ICD implantation in most patients with
      coronary heart disease and LVEF < 40%. Current Canadian guidelines recommend ICDs for primary
      prophylaxis in CAD patients with LVEF < 30% (Class I recommendation). There are very sparse
      data to recommend ICD implantation in patients with EF between 30 and 40 %. This study will
      randomize patients with CHD and an EF between 30 and 40% to ICD therapy vs. No ICD therapy.
      The primary outcome is mortality and the study is powered as a non-inferiority trial to test
      the hypothesis that mortality in patients with no ICD is not more than 1% greater (absolute
      yearly increase) than patients receiving an ICD.
    
Drug