FEDER - URN - AXONE-GLIOMA
Kohesio
UNIVERSITE DE ROUEN-NORMANDIE
Background of the proposalGlioblastoma multiforme is a glioma, a tumor of glial origin. It is the most common primary tumor of the central nervous system in adults, associated with very high morbidity and mortality, particularly due to its very invasive nature1. Particularly aggressive, these tumors give rise to almost systematic recurrences and the median survival after resection, radiotherapy and/or chemotherapy is less than 15 months. This poor prognosis is partly linked to the invasive nature of glial tumor cells, which actively infiltrate the brain parenchyma, being able to migrate away from the main tumor mass. These disseminated cells escape focal therapies and can give rise to new tumor foci distant from the initial tumor1. Understanding the mechanisms favoring the dissemination of cancer cells in the brain is therefore necessary to consider new therapeutic avenues and the development of curative treatments. In the brain, glioblastoma cells infiltrate the breast parenchyma by borrowing elements of pre-existing tissue. They migrate mainly along blood vessels and along the fibrous tracts of the white matter, and more rarely take the ventricular route2. The migration of tumor cells along blood vessels is well characterized and leads to damage within the gliovascular unit, a breakdown of the blood-brain barrier, accompanied by a probable deficit in nutrient supply3. The migration of tumor cells along myelinated nerve fibers has been poorly characterized. It has long been relegated to the rank of a simple passive process, with the white matter providing a permissive environment of low resistance for the migration of single tumor cells or in small groups4. However, recent data suggest that these invasion phenomena could be more complex5 and modulated by the activity of the local tumor environment; See attached file
Smarter Europe / Research and innovation / Research and innovation infrastructure (public)