Intestinal Remodeling And Reprogramming of Glucose Metabolism Following Laparoscopic Roux-en-Y Gastric Bypass
Society of American Gastrointestinal and Endoscopic Surgeons
Duke University

      The purpose of this study is to investigate small intestinal remodeling and reprogramming of
      glucose metabolism in patients with Type 2 Diabetes Mellitus (T2DM) who undergo laparoscopic
      Roux-en-Y Gastric Bypass (RYGB). Our specific goal is to determine if the gene and protein
      expression levels of GLUT-1 are up regulated in the Roux limb and whether this is a major
      mechanism for the remission of T2DM following RYGB.

      The two aims of the study are: 1) to demonstrate that the basement membrane glucose
      transporter 1 (GLUT-1) is upregulated in the Roux limb following RYGB, and 2) to demonstrate
      that the upregulation of GLUT-1 is a major mechanism for the improvement in glycemic control
      observed in T2DM patients undergoing RYGB.
    
Other