FEDER - URN - MOTHER OF PEARL - SPRINGBOARD
Kohesio
UNIVERSITE DE ROUEN-NORMANDIE
Currently, and more particularly in the pharmaceutical field, many substances discovered or in development are composed of chiral molecules. They can therefore exist in the form of two isomers with identical physicochemical properties but with different, or even opposing, biological activities and often only one of the two enantiomers has the required therapeutic activity. The development of processes allowing access to pure enantiomers (chiral resolution processes) therefore constitutes a major economic and scientific challenge. The SMS laboratory has extensive experience in the development of chiral resolution methods by crystallization (Pasteurian resolution, preferential crystallization, deracemization, preferential enrichment). It benefits from significant recognition from the scientific and industrial community in this field which results in different types of partnerships (university collaborations, research contracts, CIFRE Theses, patent filings, ANR, etc.). It is also thanks to this experience that the SMS laboratory is one of the beneficiary partners of the European ITN Marie-Curie CoRe project, (Continuous Resolution and Deracemization of Chiral Compounds by Crystallization) which started in October 2016 and will end in October 2020. The research carried out as part of the CoRe project has made it possible to highlight the need for the development of optimized processes of increased understanding and control. of the very first step of the crystallization process: nucleation. The idea that the theme of the nucleation of chiral phases should be the subject of a European request for a new ITN which would thus follow up on the research carried out within the framework of the CoRe project is now a consensus among our European partners. It is in this context that the SMS laboratory wishes to benefit from the support of the Normandy region. (see the description of the attached file)
Smarter Europe / Research and innovation / Research and innovation infrastructure (public)