Direct effects of the calcium sensing receptor on pituitary function: A translational study
Novo Nordisk Foundation
Copenhagen University Hospital
It is largely unknown why children today undergo puberty at an earlier age compared to 30 years ago. In a recent study, children were divided into two groups, where one group were given calcium supplementation, and to much surprise these children entered puberty at an earlier age. This was a very unexpected finding, which cannot be explained since the effect of calcium on puberty has never been investigated. In this project we will investigate a calcium-sensing receptor using both a mouse knock-out model, human volunteers and observations of children undergoing puberty, which will provide insight into why calcium seems to be influencing puberty and maybe help explain why it is, that children today is maturing at an earlier age than for only some decades ago.
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