Thematic Support - Nutrition Planetary Health
Medical Research Council
London School of Hygiene and Tropical Medicine
Emerging nations such as The Gambia suffer a double burden of malnutrition: rates of undernutrition in mothers and young children are gradually diminishing but remain a major threat to health and well-being; meanwhile rates of overweight and obesity are escalating rapidly with the attendant risks of diabetes and hypertension. The Nutrition & Planetary Health (N&PH) Theme focuses on discovery science in 5 focus areas to better identify diet-disease pathways in order to devise and test more effective next-generation interventions. Early Growth & Development: Having identified pre- and very early post-natal effects on cognitive outcomes this sub-theme is trialling novel supplementary feeding approaches to optimise brain development. Iron, Infection & Anaemia: Having recently identified novel pathways by which hepcidin-mediated blockade of iron uptake contributes to iron deficiency our research is trialling novel interventions focussed particularly on very early iron supplementation of breast-fed babies. The effects of early life iron deficiency on immune function and vaccine responses are key topics. Nutritional Genetics & Epigenetics: We have demonstrated that a mother’s nutritional status at the time of conception influences the methylation of certain genomic regions. We hypothesise that this constitutes a system to sense the external environment, record the information and adapt the developing fetal phenotype accordingly. We have evidence that these loci are under genetic control and can alter life-long risk of disease. Reaching a fuller understanding of the mechanisms and sequelae of these changes may help inform future nutritional guidance and/or interventions for mothers-to-be. Nutrition-Related Chronic Diseases: Burgeoning levels of overweight and obesity, and an ageing population in Africa are leading to multiple chronic diseases. Our research aims to characterise the nature and causes of diabetes, hypertension, sarcopenia and fractures in both rural and urban populations with a view to guide the development of Africa-specific therapeutics. Planetary Health: In response to the growing threats posed by climate change and planetary degradation we are rapidly growing a portfolio of research aimed at designing local and pan-African adaptive strategies built upon a clearer understanding of the complex interactions between agriculture and food systems, alterations in land use, and human-animal interactions.
2.1 Biological and endogenous factors / Unit